HORMONAL TREATMENT OF ENDOMETRIOSIS: CASE HISTORIES
Posted: under Women's Health.
Julie’s story
I am one of the few people who suffered virtually no symptoms of endometriosis. It was discovered when a laparoscopy was performed because I had an infertility problem. I have been married for two and a half years and a slight hormonal imbalance was found to be a contributing factor to my problem. We were trying for our first child.
I was put on a course of Danazol — three times per day for six months. But I didn’t just take it straight away
The gynaecologist told me in hospital that he was giving me a tablet that I would take for six months. As he was at the door I called out to him ‘Any side effects?’ and he answered ‘Weight gain and a few pimples’. Then he was gone.
Two weeks later I received a prescription in the mail. I assumed that I was supposed to just go to the chemist, get the pills and start taking them. But I didn’t. I wasn’t going on to any hormone drug therapy until I was satisfied that it was perfect safe for me. I have several reasons that make me a special case, including a breast lump removed and diagnosed as ‘pre-cancerous’.
For the next three months I asked anyone who might know about Danazol and its effects. I considered alternative treatments such as Chinese herbal medicine. I was looking for anything that might stop me taking Danazol!
I was scared! I read all the information sent from the Endometriosis Association. The list of side effects and percentage of people to experience them looked terrible!
How much weight do you gain? How much hair do you get on your face? Does your voice go really deep? Will I start ovulating again when I come off Danazol? Does Danazol really cure endometriosis? The list goes on.
Finally, after a few chats with my GP and the Association (who were both extremely helpful), I decided to wait three months. My circumstances had changed and we thought that if I were more relaxed I might conceive anyway.
No luck. So I went on the Danazol. After three weeks I noticed a decrease in breast development. I started getting frequent muscle cramps — all over. My voice started to get a little hoarse — only after talking for a while and certainly not all day every day. After five to six weeks my skin started to get oily and pimply. My weight steadily increased — by 21 weeks I had gained at least eight kilograms. But I was underweight to start and now everyone tells me I look better. Most of this weight is due to my extraordinary muscular broad shoulders — another side effect.
I have four weeks and two days to go. The worst side effect I have had would be the oily skin and acne.
My message is this. Find out all you can about the treatment and side effects and decide on how you will cope. Don’t be scared off by figures and long lists that you read or hear about. Talk to as many people as possible. The side effects are really not bad at all — and not as severe as you may think. For example, you won’t get so much hair on your face that you have to shave! Most people will not notice any change in you at all.
Lisa’s story
I am a professional entertainer. As a teenager, my periods had never been of concern to me. However, at the age of 29 I developed severe period pain and heavy bleeding and found it impossible to continue performing for the first two days of my period.
I consulted my GP who was surprised I was having days off work due to period pain, so immediately referred me to a gynaecologist. After listening to my symptoms he asked me a few questions. He asked if I had pain on intercourse. I finally conceded that I did, but only at certain times during the month. He asked if I suffered from backache. I answered that I did but I had put it down to my long hours of stage entertaining. He wanted to know if I had any bowel problem. I admitted that I sometimes had bouts of pain and diarrhoea but I put that down to my irregular eating habits.
After considering all my answers the gynaecologist said he drought I had endometriosis and that he wanted to perform a laparoscopy the following week.
After the laparoscopy I was shocked when I was told I had severe endometriosis and two options were to take Danazol or have a baby. I told him I did not want to have a baby, then or in the future. He said to think carefully about having a baby because it might be one way of curing die disease.
I asked him about the other option, Danazol. He was frank with me and told me the side effects that I might develop. Then the bombshell hit — he informed me that there was a remote chance that the Danazol could cause an irreversible deepening of my voice.
I didn’t want to believe what I was hearing. First, I was told to get pregnant but I didn’t want a baby. Second, I was told to take a drug that could ruin my career. I didn’t know what to do or where to turn.
My gynaecologist realised how upset I was and suggested I could try another drug called Duphaston. He told me that it was a synthetic progesterone and therefore didn’t have the same side effects as Danazol. I was willing to try this drug. I was to take 30 milligrams of Duphaston daily for nine months.
I have just completed the course of Duphaston and I can honestly say I feel a lot better. I had a few side effects whilst taking Duphaston but nothing I couldn’t accept. I had tender breasts and nausea in the morning. I continued to menstruate but the pain subsided after two months and my periods weren’t nearly so heavy.
I am now looking forward to once again putting all my energies into my career in entertainment.
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